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Yonetani–Theorell plot of MMP-13 fTHP-15 hydrolysis in the presence of (A) 6 and 1, (B) 4 and 1, and (C) 5 and 1. Note the nonparallel lines of best fit indicating mutually nonexclusive binding by two inhibitors. B < 1, indicating synergistic binding for all three pairs of inhibitors tested.
