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. 2014 Oct 20;57(22):9598–9611. doi: 10.1021/jm501284e

Figure 5.

Figure 5

Results of protease panel profiling assays. Test compounds were screened in 12-point 3-fold dilution dose–response curve format. The activity of each enzyme was determined as the conversion (%) of the substrate to product after 3 h of incubation. (A) Metalloprotease panel results at the highest compound concentration tested. (B) Serine, cysteine, and aspartic protease panel results at the highest compound concentration tested.