Table 1.

Data sources used to explore the different biomedical dimensions of the project and for validation purposes.

Data-sets	Data-types	Reference	Brief Description.
BioBridge	Metabolomics, Proteomics, Transcriptomics, Physiological and Clinical Measurements	[27], [83], [84],	COPD patients with low and normal fat free mass index and healthy subjects studied before and after training.
PAC-COPD	Clinical Measurements and Co-morbidity data.	[75]	COPD patients studied after the first hospitalization because of an episode of exacerbation.
Medicare	ICD9 codes from hospital registries.	[85], [85]	Health Insurance Program
Animal experiments	Muscle Transcriptomics and muscle & blood Cytokines. Role of eiF6 in energy metabolism	Synergy-COPD-FP7-ICT-270086:2010-13.	Guinea Pig and mice models, C2C12 cell culture. Normoxic and hypoxic conditions
Public datasets	SNOMED-CT, MeSH, angiogenesis-related expression data, etc.	See Table 1 in COPDKB [35]	Public resources integrated into the Synergy-COPD Knowledge Base.