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. 2014 Nov 14;5(1):52. doi: 10.1186/2049-1891-5-52

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© Li; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Major functions of TGFβ superfamily signaling in the female reproduction. TGFβ superfamily signaling regulates a variety of reproductive processes including follicular development (e.g., TGFβs, GDF9, BMP15, activins, and AMH), ovulation (e.g., GDF9), oocyte competence (e.g., GDF9 and BMP15), decidualization (e.g., BMP2 and NODAL), implantation (e.g., ALK2-mediated signaling), pregnancy (e.g., BMPR2-mediated signaling), embryonic development (e.g., TGFβs, activins, follistatin, BMP2, and BMP4), and uterine development (TGFBR1-mediated signaling).