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. 2014 Nov 29;15:131. doi: 10.1186/s12868-014-0131-5

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© Wong et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of hypertension on outcome following MCAO and progesterone treatment. The percentage of animals survived post-surgery over time (A). Mortality data expressed using the Kaplan-Meier curve and analysed using the Mantel-Haenszel log-rank test showed no significant difference between groups in % of surviving animals. All BPH/2 mice significantly lost body mass after surgery (P = 0.0001) but progesterone treatment did not affect the amount of body mass loss (B). Progesterone treatment reduced neurological deficit (C) compared to controls (***P = 0.0001). Contralateral foot-faults (%) were assessed in BPH/2 mice on the day following surgery (D) and there was no difference found between progesterone and non-treated mice (P = 0.0679). Number of animals per group are shown in parentheses and all data (B-D) are expressed as mean ± SEM.