Table 2.
Sham | Progesterone | Vehicle/Non-treated | ||||
---|---|---|---|---|---|---|
Day | Outcome | Adult C57 Bl/6 | Adult C57 Bl/6 | Hypertensive | Adult C57 Bl/6 | Hypertensive |
5 | % Alternation | 16.67 ± 7.45 | 33.33 ± 16.67 | |||
% Contralateral/Ipsilateral Ratio | 34.29 ± 12.45 | 61.90 ± 20.76 | ||||
Time Taken (mins) | 3.31 ± 0.27 | 3.81 ± 0.27 | ||||
6 | % Alternation | 16.67 ± 10.54 | 11.11 ± 11.11 | |||
% Contralateral/Ipsilateral Ratio | 25.71 ± 17.14* | 95.24 ± 4.76 | ||||
Time Taken (mins) | 3.51 ± 0.27* | 5.52 ± 0.80 | ||||
7 | % Alternation | 58.34 ± 4.81 | 38.89 ± 12.67 | 26.67 ± 16.33 | 50.00 ± 9.62 | 33.33 ± 19.25 |
% Contralateral/Ipsilateral Ratio | 57.14 ± 5.83 | 54.62 ± 14.03 | 17.14 ± 10.50 | 57.14 ± 14.29 | 71.43 ± 14.29 | |
Time Taken (mins) | 7.78 ± 0.94 | 6.27 ± 0.91 | 3.84 ± 0.35* | 5.59 ± 0.21 | 5.59 ± 0.76 |
There was no significant difference between groups in terms of % alternation rate, contralateral/ipsilateral alternation ratio (%), or time taken to complete trials in adult mice (progesterone n = 6, vehicle n = 3, sham n = 4). In hypertensive BPH/2 mice, there was no difference found between progesterone and non-treated groups in t-maze alternation %, but progesterone treated animals had a significantly greater contralateral goal arm preference than non-treated groups (P = 0.0006). Data expressed as mean ± SEM (progesterone n = 5, vehicle n = 4).