Table 2.

T-maze data for animals following MCAO

		Sham	Progesterone		Vehicle/Non-treated
Day	Outcome	Adult C57 Bl/6	Adult C57 Bl/6	Hypertensive	Adult C57 Bl/6	Hypertensive
5	% Alternation			16.67 ± 7.45		33.33 ± 16.67
	% Contralateral/Ipsilateral Ratio			34.29 ± 12.45		61.90 ± 20.76
	Time Taken (mins)			3.31 ± 0.27		3.81 ± 0.27
6	% Alternation			16.67 ± 10.54		11.11 ± 11.11
	% Contralateral/Ipsilateral Ratio			25.71 ± 17.14*		95.24 ± 4.76
	Time Taken (mins)			3.51 ± 0.27*		5.52 ± 0.80
7	% Alternation	58.34 ± 4.81	38.89 ± 12.67	26.67 ± 16.33	50.00 ± 9.62	33.33 ± 19.25
	% Contralateral/Ipsilateral Ratio	57.14 ± 5.83	54.62 ± 14.03	17.14 ± 10.50	57.14 ± 14.29	71.43 ± 14.29
	Time Taken (mins)	7.78 ± 0.94	6.27 ± 0.91	3.84 ± 0.35*	5.59 ± 0.21	5.59 ± 0.76

There was no significant difference between groups in terms of % alternation rate, contralateral/ipsilateral alternation ratio (%), or time taken to complete trials in adult mice (progesterone n = 6, vehicle n = 3, sham n = 4). In hypertensive BPH/2 mice, there was no difference found between progesterone and non-treated groups in t-maze alternation %, but progesterone treated animals had a significantly greater contralateral goal arm preference than non-treated groups (P = 0.0006). Data expressed as mean ± SEM (progesterone n = 5, vehicle n = 4).