Table 2.
Summary of pooled odds ratios (OR) with confidence intervals (CI) of the GSTM1 polymorphism and gastric cancer risk
| Group of analysis | n † | GSTM1 (Null vs. Present*) | M # | Heterogeneity | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P OR | I 2 (%) | P Q ※ | |||
| Overall | 54 | 1.207(1.106-1.317) | <0.001 | R | 49.9 | <0.001 |
| Ethnicity | ||||||
| Asians | 24 | 1.264(1.164-1.422) | <0.001 | R | 51.8 | 0.002 |
| Caucasians | 29 | 1.154(1.008-1.321) | 0.037 | R | 50.6 | 0.001 |
| Negroids | 1 | 1.182(0.142-9.827) | 0.887 | F | —¶ | —¶ |
| Smoking status | ||||||
| Non-smokers | 14 | 1.370(1.043-1.800) | 0.024 | R | 46.7 | 0.028 |
| Ever-smokers | 14 | 1.558(1.111-2.183) | 0.010 | R | 69.6 | <0.001 |
| Alcohol drinking | ||||||
| Non-drinkers | 4 | 0.872(0.623-1.220) | 0.425 | F | 0.0 | 0.757 |
| Ever-drinkers | 4 | 1.112(0.771-1.602) | 0.570 | F | 0.0 | 0.905 |
| Helicobacter pylori infection | ||||||
| Helicobacter pylori negative | 7 | 0.869(0.654-1.156) | 0.334 | F | 6.8 | 0.373 |
| Helicobacter pylori positive | 7 | 1.595(1.104-2.304) | 0.013 | R | 49.9 | 0.076 |
†Number of studies included.
*The genetic comparison model for GSTM1–GSTT1interaction analysis is Dual null genotype vs. Non-null genotype.
# M, model of meta-analysis; R, random-effects model; F, fixed-effects model.
※ PQ: P values of Q-test for heterogeneity test.
¶Values could not be calculated out.