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. 2014 Nov 26;9:178. doi: 10.1186/s13023-014-0178-5

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© Schelleckes et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Magnetic resonance imaging (MRI) and small fiber neuropathy diagnosis by PGP9.5 immunofluorescence. (A-C) Fluid attenuated inversion recovery (FLAIR) MRI of patient #1 showed multiple, punctuated white matter lesions from periventricular (yellow arrows and circles) to subcortical (red arrows and circles) without gadolinium enhancement. (D) Skin biopsy analysis of patient #2 showed the reduction of the small epidermal nerve fibers (arrow). Scale bar = 20 μm. (E-F). The number of focal axonal swellings (arrows) larger than 1.5 μm was increased. Scale bar = 10 μm. (G) Skin biopsy of a healthy control. Scale bar = 30 μm.