Table 2.

Cytokines regulating eosinophilia

Cytokine	Family	Effect on Eosinophils	Other Relevant Functions
TNF-α [59,60]	Monokine	CAM expression, recruitment	Vascular permeability increase, eosinophil degranulation
IL-1β [59,60]	Monokine	CAM expression, eosinophil recruitment	Eosinophil activation, eosinophil degranulation
IL-3 [59]	HP	survival, differentiation	Multipotential HP
IL-4 [59,60]	Th2	VCAM expression on EC	IgE synthesis
IL-5 [59]	Th2	Hematopoiesis, activation, survival, mediator	IgA synthesis
IL-13 [59,60]	Th2	VCAM expression on EC	IgE synthesis, Mucus production
GM-CSF [59,60]	Th1/2	Activation	MO activation, hematopoiesis
SCF [59]	HP	Adhesion	Mast cell growth
Eotaxins [59]	Chemokine	Chemoattractant	Multipotential HP
MCPs [59,60]	Chemokine	Chemoattractant	MO chemotaxis
RANTES [59,60]	Chemokine	Chemoattractant	Histamine release from basophils

CAM, Cell Adhesion Molecule; EC, endothelial cells; CSF, Colony Stimulating Factor; Th2, type 2 T helper cell; HP, hematopoietin; APR, acute phase response, MO, Monocyte-macrophage lineage cells; VCAM-vascular cell adhesion molecule; MCP-monocyte chemoattractant protein-1