Table 2.

Amino acid diversity (expressed as a percentage ± S.E.) in domains of vertebrate transferrin clades¹.

Clade	Protein Region
	Positively Charged Region 1	Positively Charged Region 2	Remainder N-lobe	C-lobe	Entire Protein
S	34.5 ± 4.5 %*2	23.5 ± 5.8%	24.4 ± 1.6%	27.1 ± 1.7%	26.1 ± 1.2%
ICA	34.9 ± 4.0 %	28.0 ± 6.5%	26.6 ± 1.7%	20.1 ± 1.5%**	23.5 ± 1.0%
L	47.6 ± 4.9 %***	32.7 ± 7.2%	29.7 ± 1.7%	27.0 ± 1.6%	29.6 ± 1.1%
O	48.6 ± 5.1 %**	54.0 ± 6.5%**	34.0 ± 1.7%	40.3 ± 1.7%**	39.1 ± 1.2%
M	42.6 ± 4.8 %*	40.6 ± 7.4%	30.8 ± 1.6%	32.2 ± 1.4%	32.4 ± 1.0%
M-like	30.0 ± 4.0 %	40.8 ± 8.2%	32.6 ± 1.8%	32.3 ± 1.7%	32.4 ± 1.2%

¹Clades are as in Figure 2.

²Z tests (2-tailed) of the hypothesis that the amino acid diversity equals that of the remainder of the N-lobe:

^*P < 0.05;

^**P < 0.01;

^***P < 0.001.