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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Clin Sci (Lond). 2014 May;126(10):727–738. doi: 10.1042/CS20130385

Figure 1. Regulation of MAS promoter.

Figure 1

Conservation of the MAS promoter in multiple mammalian species. Red represents regions of high conservation, green repetitive elements, blue coding segments, and yellow the UTR sequence as determined with the ECR browser. Known SNPs are shown, with each black line representing an SNP. Three promoter sites (A, B, and C) were identified as highly conserved. Site C contains no known SNPs and also several transcription factor binding sites as identified in ENCODE. The proximal promoter for MAS (orange) was cloned into a pGL3 luciferase reporter vector. The proposed transcriptional start site (TSS) for humans based on primate UTR sequence analysis has a TATA box located 24 bases upstream the TSS.