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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Clin Sci (Lond). 2014 May;126(10):727–738. doi: 10.1042/CS20130385

Figure 5.

Figure 5

A) Proposed mechanism for the fold back of element C of the MAS promoter to regulate the transcriptional control of MAS through interaction of ZNF274 and SRY recruiting KAP1. Nitration in the KRAB domain may lead to the differential regulation of the MAS promoter following Ang-(1-7) activation and possible nitration of transcription factors. The hypertensive SHR animal contains an additional copy of Sry which may facilitate additional binding to the promoter sequence thus recruiting additional KRAB domains when compared to the normotensive WKY animal. B) Proposed nuclear mechanism involving nitric oxide repression of the KRAB/KAP1 complex on promoters of multiple RAS genes as a result of activation of MAS and AT2 by Ang peptides.