Table 1.
Thirteen cases of IVIG therapy in PG (all IVIG courses were 2 g/kg unless noted otherwise)
| Age, gender, ref. | Notable past medical history | Initial therapy | Initial IVIG courses | Initial response | Relapse | Therapy during IVIG treatment | Number of further IVIG courses | Subsequent response | Follow-up |
|---|---|---|---|---|---|---|---|---|---|
| 35, F [2] | insect bite | PRD, DAP, CBT, TAC, CSA, MPD | 2 (2 weeks apart) | nearly complete | no | PRD, CSA | none | N/A | clear at 8 months |
| 48, M [3] | adrenal carcinoma, pemphigus vulgaris | PRD, MMF, CSA, DEX, THL | 1 | complete | yes | PRD, MMF | yes, 1 course | complete | clear at 5 months |
| 17, F [3] | none noted | PRD, MPD, MMF, CSA | multiple (number and interval not given) | nearly complete | yes | CSA, MMF | yes | complete | clear at 15 months |
| 37, F [4] | none noted | PRD, CSA | 4 (monthly) | complete | no | PRD | none | N/A | clear at 4 months |
| 55, M [5] | Ph+ CML | PRD, MCN, DAP, AZA, MMF, SSKI, CSA | 3 (monthly) | complete | no | PRD | yes, indefinite | complete | clear at 8 months |
| 81, M [6] | trauma | CSA | 6 (monthly) | significant | no | MPD | none | N/A | clear at 7 months, then died of cardiac arrest |
| 58, M [7] | prostate carcinoma | PRD, MCN | 6 (monthly) | significant | no | PRD | none | N/A | stable at 12 months |
| 66, M [7] | CMML | BTM, TAC, PRD | 6 (monthly) | significant | no | PRD | none | none | stable at 6 months |
| 83, M [8] | none noted | CBT, MCN, PRL | 5 (monthly) | significant | no | none | yes, 5 courses (bi-monthly) | complete | stable at 15 months |
| 61, F [9] | RA, insect bite | PRD | 3 (monthly) | marked | no | PRD | no | N/A | stable (unknown) |
| 62, F [10] | none noted | CSA, GC | 4 (monthly)a | complete | no | PRD | no | N/A | stable at 12 months |
| 61, M [11] | MDS | PRL, MPD | 2 (monthly) | marked | no | PRL, PRD | no | N/A | stable at 3 months |
| 26, F [12] | twin pregnancy | DAP, MPD | 4 (monthly)b | significant | no | MPD | no | N/A | stable (unknown) |
The authors defined all clinical responses – there is no uniform standard for clinical response in PG.
AZA = Azathioprine; BTM = betamethasone (topical); CBT = clobetasol (topical); CMML = chronic myelomonocytic leukemia; CSA = cyclosporine A; DAP = dapsone; DEX = dexamethasone; GC = glucocorticoid (drug/route not specified); MCN = minocycline; MDS = myelodysplastic syndrome; MMF = mycophenolate mofetil; MPD = methylprednisolone; Ph+ CML = Philadelphia chromosome-positive chronic myeloid leukemia; PRD = prednisone; PRL = prednisolone; RA = rheumatoid arthritis; SSKI = potassium iodide; TAC = tacrolimus (topical); THL = thalidomide.
IVIG course 2.5 g/kg.
IVIG course 1.5 g/kg.