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. 2014 Dec 4;10(12):e1003926. doi: 10.1371/journal.pcbi.1003926

Figure 1. Workflow of the ECOD automatic domain classification pipeline.

Figure 1

Unclassified structures enter from the top (white). Firstly, peptides, coiled-coils, and other unclassifiable regions are removed where possible and placed in their respective special architectures (orange). Secondly, unassigned regions of the input sequence are iteratively assigned by descending best hits from BLAST and HHsearch-based searches of ECOD databases. Assemblies of putative domains are optimized and assigned (green). If the chain is incomplete by sequence, a similar process occurs using DaliLite searches. If the query remains unclassified, it is manually curated (yellow).