Table 1. Point mutations suggested for the three putative O2 channels.
Residue | Location | Suggested Mutations |
W172I | Channel 1 | less bulkier side-chain residues (e.g. Y or F) |
F282I | Channel 1 | less bulkier side-chain residues (e.g. T, V, A, G) |
L292I | Channel 2 | longer and bulkier side-chain residues (e.g. M or F) |
I323I | Channel 2 | longer and bulkier side-chain residues (e.g. M or F) |
I363I | Channel 3 | longer side-chain residues (e.g. L or M) |
V72II | Channel 3 | longer side-chain residues (e.g. L or M) |
V107II | Channel 3 | bulkier side-chain residue (e.g. F) |