Figure 3. Reduced TTBK1 protects against TDP-43 phosphorylation.

(A) NSC-34 cells treated with siRNA targeting TTBK1 exhibit reduced TDP-43 phosphorylation following induction of P-TDP-43 with ethacrynic acid (EA). (B) Quantitative analysis of band intensities from three independent replicate siRNA experiments. Band intensities are graphed in arbitrary units. *P = 0.025 versus control+EA, Student's t-test.