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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Acta Biomater. 2014 Oct 2;11:27–36. doi: 10.1016/j.actbio.2014.09.032

Figure 7.

Figure 7

Histological evaluation of silk and agarose hydrogel cartilage constructs. (A) Alcian blue staining was used to visualize glycosaminoglycan (GAG) content within hydrogel constructs. Arrows indicate co-localization of GAGs around silk microfibers in SF–silk hydrogels, a phenomenon not observed in SF–agarose hydrogels. Immunohistochemistry of (B) collagen type II and (C) collagen type I. Collagen type II was found in a higher abundance in the no-fiber agarose control constructs compared to all other groups. Insert boxes represent negative staining.