Table 3.

Pooled analysis of the association between rs686 and lung cancer risk stratified by exposure to environmental tobacco smoke during childhood

	Unexposed to SHS During Childhood							Exposed to SHS During Childhood
Gene	Control	Case	OR	LCI	-	UCI	P-value	Control	Case	OR	LCI	-	UCI	P-value
All1	542	410	1.01	0.83	-	1.24	0.891	980	965	0.71	0.62	-	0.82	<0.0001
European American2	269	223	0.90	0.68	-	1.18	0.449	488	493	0.65	0.53	-	0.80	<0.0001
African American3	269	182	1.17	0.87	-	1.57	0.311	488	466	0.73	0.62	-	0.88	0.001
Ever Smokers4	202	219	1.17	0.86	-	1.57	0.311	545	733	0.74	0.62	-	0.88	0.001
Never Smokers5	340	190	0.91	0.69	-	1.21	0.513	434	223	0.61	0.47	-	0.79	<0.0001
Male6	322	238	1.13	0.86	-	1.47	0.391	507	532	0.70	0.58	-	0.86	<0.0001
Female6	220	172	0.87	0.63	-	1.19	0.381	473	433	0.71	0.58	-	0.87	0.001

¹Adjusted for age, gender (male/female), race (AA/EA), study (NCI-MD/Mayo Clinic/Wayne State), smoking status (never/ever), smoking exposure as an adult and pack-years of smoking

²Adjusted for age, gender (male/female), smoking status (never/ever), study (NCI-MD/Mayo Clinic), smoking exposure as an adult and pack-years of smoking

³Adjusted for age, gender (male/female), smoking status (never/ever), study (NCI-MD/Wayne State), smoking exposure as an adult and pack-years of smoking

⁴Adjusted for age, gender (male/female), race (AA/EA), pack-years of smoking, study (NCI-MD/Mayo Clinic/Wayne State), secondhand smoking exposure as an adult and pack-years of smoking

⁵Adjusted for age, gender (male/female), race (AA/EA), study (NCI-MD/Mayo Clinic/Wayne State), secondhand smoking exposure as an adult

⁶Adjusted for age, race (AA/EA), smoking status (never/ever), study (NCI-MD/Mayo Clinic/Wayne State), smoking exposure as an adult and pack-years of smoking

OR denotes odds ratio, 1df test, UCI, upper confidence limit, LCI, lower confidence limit