Table 1.

Of the many parameters that can modulate the host inflammatory response to a fibrous scaffold, we first reduced an initial set of 20 (listed in the left column) to a focused set of 10 (highlighted in grey), which in turn was reduced to a final set of 6 (in bold) parameters that were used for non-dimensionalization (cf. Table 2) and the subsequent computational study. References for each parameter are classified as (i) from the general biomaterials literature or specific to vascular applications, and (ii) by the experiments performed in vitro versus in vivo, which in turn were either sub-cutaneous (SQ) or tissue specific (TS). Note that review articles are only classified by (i).

Parameters	General Biomaterials	Vascular Specific	In vitro	In vivo (SQ)	In vivo (TS)
Chemical side groups	53,56	12,15	53	53
Composition	11	15,54	11,54	11	54
Contact duration	18,53,55,56	15	18,53	53,55
Filament structure	63		63	63
Host-dependencies	53	12	53	53
Material weight		64			64
Morphology	9,28	15	28	9,28
pH end products	63	64	63	63	64
Sterility		15
Topography	11,26,28,62	15,54	11,26,28,54	11,28	54
Roughness	11,26,62	15	11,26	11
Shape	9,26,53	15	26,53	9,53
Surface chemistry	11,43,55,62,63	12,15,54,61,65	11,43,54,61,63,65	11,55,61,63	54
Wettability	9,11	12,15,61	11,61	9,11,61
Degradation rate	9,53	12,15,57	53	9,53	57
Porosity	9,20,53,55,58–60	15,54,61	20,53,54,58,60,61	9,53,55,59,61	54
Stiffness	53,66	12,15,54,67,68	53,66,67	53	54,6 8
Fiber diameter	10,18,24,25,26,28,43,60,63,69	12,17,46,65,67	17,18,25,26,28,43,46,60,63,65,67	10,24,28,63,69	46
Pore size	10,18,20,24,45,53,58–60	12,46,61,67	18,20,46,53,58,60,61,67	1,450,24,53,59,61
Alignment	11,26,28	12	11,26,28	11,28