Table 3.

Association of Urinary Albumin-to-Creatinine Ratio with Cardiac Parameters: Unadjusted and Multivariable-Adjusted Linear Regression Analyses

Cardiac parameter	Unadjusted		Model 1		Model 2		Model 2 (UACR < 300 mg/g)*
	β-coefficient** (95% CI)	P-value	β-coefficient (95% CI)	P-value	β-coefficient (95% CI)	P-value	β-coefficient (95% CI)	P-value
	RV wall thickness	0.09 [0.04, 0.14]	0.001	0.09 [0.04, 0.14]	0.001	0.08 [0.02, 0.13]	0.01	0.14 [0.06, 0.22]	0.001
RV fractional area change	−0.56 [−0.98,−0.14]	0.01	−0.55 [−0.97,−0.13]	0.01	−0.52 [−1.01,−0.03]	0.04	−0.97 [−1.72,−0.23]	0.01
PRSW	−2.16 [−3.57,−0.74]	0.003	−2.05 [−3.48,−0.62]	0.01	−1.62 [−3.1,−0.15]	0.03	−2.24 [−4.50, 0.02]	0.05
Tissue Doppler s′ velocity	−0.19 [−0.34,−0.05]	0.01	−0.20 [−0.35,−0.06]	0.01	−0.12 [−0.29, 0.04]	0.14	−0.07 [−0.33, 0.20]	0.62
Log BNP	0.21 [0.14, 0.29]	<0.001	0.23 [0.16, 0.30]	<0.001	0.17 [0.10, 0.25]	<0.001	0.19 [0.07, 0.31]	0.003

^*Subgroup analysis of study participants without macroalbuminuria (N=124)

^**All β-coefficients shown represent change in cardiac parameter per doubling of UACR

Model 1: Adjusted for age, sex, and African-American race

Model 2: Adjusted for age, sex, African-American race, pulse pressure, diabetes mellitus, coronary artery disease, estimated glomerular filtration rate, and left ventricular mass

UACR = urinary albumin-to-creatinine ratio; RV=right ventricular, PRSW = preload-recruitable stroke work