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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Nov 10;21(12):1082–1090. doi: 10.1038/nsmb.2915

Figure 8.

Figure 8

A model of CED-3-activated suppression of AKT signaling by CNT-1 in C. elegans. In non-apoptotic cells, some AKT kinases are recruited to the plasma membrane and activated by PIP3 to transduce the survival signal. In apoptotic cells, CNT-1 is cleaved by activated CED-3 to generate potent phosphoinositide-binding tCNT-1, which translocates to the plasma membrane from the cytoplasm. tCNT-1 outcompetes AKT kinases for binding to PIP3 and thus displaces and inactivates AKT kinases, leading to loss of the survival signal and apoptosis.