Table 3.
Antibiotics prescribed during the hospitalization and at discharge
| Diabetes mellitus N = 167 |
No diabetes mellitus N = 603 |
P | |
|---|---|---|---|
| Individual antibiotics prescribed during the inpatient stay a, b | |||
| Vancomycin | 142 (85) | 504 (84) | 0.65 |
| Clindamycin | 27 (16) | 131 (22) | 0.12 |
| Parenteral β-lactam/β-lactamase inhibitor | 70 (42) | 200 (33) | 0.04 |
| 2nd generation or higher cephalosporin | 13 (8) | 51 (8) | 0.78 |
| Cefazolin | 17 (10) | 91 (15) | 0.11 |
| Carbapenem | 9 (5) | 34 (6) | 0.90 |
| Fluoroquinolone | 20 (12) | 53 (9) | 0.21 |
| Daptomycin | 8 (5) | 24 (4) | 0.64 |
| Linezolid | 2 (1) | 8 (1) | 1.00 |
| Other β-lactam | 6 (4) | 30 (5) | 0.45 |
| Trimethoprim-sulfamethoxazole | 12 (7) | 30 (5) | 0.27 |
| Doxycycline | 15 (9) | 44 (7) | 0.47 |
| Cephalexin | 7 (4) | 22 (4) | 0.74 |
| Amoxicillin-clavulanate | 11 (7) | 24 (4) | 0.15 |
| Antibiotics prescribed at hospital discharge b | 163 (98) | 580 (96) | 0.38 |
| Clindamycin | 20 (12) | 95 (16) | 0.23 |
| Trimethoprim-sulfamethoxazole | 52 (31) | 215 (36) | 0.28 |
| Doxycycline | 32 (19) | 91 (15) | 0.20 |
| Cephalexin | 12 (7) | 46 (8) | 0.85 |
| Amoxicillin-clavulanate | 24 (14) | 82 (14) | 0.80 |
| Fluoroquinolone | 18 (11) | 32 (5) | 0.01 |
| Linezolid | 8 (5) | 19 (3) | 0.31 |
| Other oral β-lactam | 3 (2) | 28 (5) | 0.10 |
| Other oral antibiotic | 1 (1) | 2 (0.3) | 0.52 |
| Vancomycin | 8 (5) | 15 (2) | 0.13 |
| Daptomycin | 5 (3) | 10 (2) | 0.34 |
| Other parenteral antibiotic | 4 (2) | 11 (2) | 0.75 |
| Antibiotic with broad gram-negative activity initiated in emergency department or urgent care | 46/149 (31) | 174/561 (31) | 0.97 |
| Exposed to any antibiotic with broad gram-negative activity c | 101 (62) | 311 (53) | 0.048 |
| Exposed to any antibiotic with anti-pseudomonal activity c | 62 (38) | 149 (25) | 0.002 |
| Exposed to at least 2 calendar days of antibiotics with broad gram-negative activity c | 89 (54) | 259 (44) | 0.02 |
| Treatment duration d | |||
| Total duration of therapy, median days (IQR) | 13 (10–15) | 12 (10–15) | 0.09 |
| Duration of inpatient therapy, median days (IQR) | 4 (3–6) | 4 (3–5) | 0.03 |
| Duration of therapy after discharge, median days (IQR) | 8 (7–10) | 8 (7–10) | 0.58 |
Data presented as n (%) unless otherwise noted. IQR, interquartile range.
a
At least one dose administered; includes antibiotics initiated by the emergency department, urgent care, or admitting clinic.
b
Patients could receive more than one antibiotic
c
Analysis limited to 752 patients (164 diabetics and 588 non-diabetics) where the antibiotic prescribed at discharge was known
d
Analysis limited to 709 patients (157 diabetics and 552 non-diabetics) with a known duration of therapy