Table 4. The rates of different classes of LOH on CHR3 in top1Δ backgrounds.

	Strain Description *
LOH Class	GTOP SAME Rate×10−8 (N)	GTOP OPPO Rate×10−8 (N)	GBTM SAME Rate×10−8 (N)	GBTM OPPO Rate×10−8 (N)
A	341 (15)	134 (9)	196 (10)	194 (37)
B	91.1 (4)	14.8 (1)	19.6 (1)	26.2 (5)
C	91.1 (4)	29.7 (2)	78.5 (4)	0 (0)
D	22.8 (1)	44.5 (3)	19.6 (1)	36.7 (7)
E **	114 (5)	490 (33)	157 (8)	26.2 (5)
F	319 (14)	623 (42)	314 (16)	131 (25)
G	68.3 (3)	29.7 (2)	216 (11)	10.5 (2)
Other	22.8 (1)	14.8 (1)	39.2 (2)	0 (0)
Total Rate×10−8 (95% CI)	1070 (563–1600)	1380 (965–2210)	1040 (749–2260)	425 (274–796)
Total N	47	93	53	81

LOH classes A–G are described in Table 2 and Figure S4.

*Strain Description: pTET-lys2-GTOP or -GBTM, SAME or OPPO replication orientation (See Fig. 3B). All data are from top1Δ backgrounds.

**Class E is defined as the LOH breakpoint occurring at the pTET –lys2-GTOP or -GBTM cassette.