Figure 3. Comparison of one-time mass vaccination, vaccination campaigns that occur every 5 years, and continuous vaccination.

The one-time vaccination targets 70% of the vaccine-eligible population (those one year old and older) for vaccination, the 5-year campaigns target 70% of the population every 5 years, and the continuous vaccination strategy targets 70% of the population at the beginning of the first year then vaccinates at a constant rate starting in year 2. Vaccine is less effective for children aged 1–4 (40% efficacy) than for older children and adults (65% efficacy). Temporal dynamics of A) the fraction of the population protected by vaccine; B) annual cholera cases; C) the overall effectiveness in terms of prevented fraction of cholera cases when different vaccination strategies are implemented; and D) total number of vaccinations for different strategies over 10 and 20 years.