Figure 1. Comparison of NONcNZO10 mice on rapamycin and control diets.

Rapa treatment suppresses body weight gain, elevates plasma glucose, and reduces plasma insulin. All 20 mice were fed 11% fat diet until 12 weeks of age, when 10 were switched to an 11% fat diet containing 14 ppm encapsulated rapamycin. (A) Body weight. (B) Plasma glucose. (C) Plasma insulin. Values ± standard error are shown from 8 to 24 weeks of age.