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. 2014 Dec 4;9(12):e114324. doi: 10.1371/journal.pone.0114324

Figure 2. Effect of rapamycin on kidney glomerular morphology in NONcNZO10 mice.

Figure 2

Untreated mice (A) show hyaline deposits, likely subendothelial, in the glomerular tuft. These deposits are greatly reduced in rapa-treated mice (B). The deposits are strongly positive for IgG in untreated mice (C), and IgG staining is greatly reduced in rapa-treated mice (D). 100 glomeruli from each mouse were scored for presence of nephritis (E) and/or hyaline thrombi deposits (F), showing quantitatively the reduction in kidney disease by rapa treatment.