Table 1. Effects of rapamycin in type 2 diabetes in NcZ10 mice: health and functional test results at end of study (26 weeks of age, 14 weeks of treatment).

Group	n	Glucose	HbA1c	TG	Total	HDLD	NEFA	ACR
		(mg/dL)	(% IFCC	(mg/dL)	Chol.	Chol.		(mg/g)
			Units)		(mg/dL)	(mg/dL)
Control	8	306±31	3.0±0.1	347±27	102±4	86±2	5.4±0.2	151±57
Rapa-treated	8–9	491±15**	5.1±0.3**	333±25	118±5*	97±4*	5.2±0.2	37±16‡

Mean ± SE. Significant difference, control vs. rapamycin-treated within strain, by ANOVA.

**p≤0.0001.

*p≤0.05.

‡p = 0.03 by nonparametric Wilcoxon rank sum used due to high variability in controls.

HbA1c  =  hemoglobin A1c; TG  =  triglycerides; chol.  =  cholesterol; NEFA  =  non-esterified fatty acids; ACR  =  albumin creatinine ratio.