Table 2. Top upstream regulators upon 1 µM Dex treatment in MM1S cells for 72 h.
| Upstreamregulator | Molecule type | P-value | Predicted activation state | Activation Z-score |
| TP53 | Transcription regulator | 1.53E-49 | Activated | 5.504 |
| CDKN1A | Kinase | 5.31E-47 | Activated | 4.322 |
| CDKN2A | Transcription Regulator | 1.80E-37 | Activated | 6.844 |
| Dexamethasone | Chemical drug | 1.14E-11 | Activated | 2.719 |
| NR3C1 | Ligand-dependent nuclear receptor | 4.58E-08 | Activated | 2.359 |
| I kappa b kinase | Complex | 4.09E-07 | Activated | 2.629 |
| PPARG | ligand-dependent nuclear receptor | 1.35E-05 | Inhibited | −2.804 |