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. 2014 Dec 4;10(12):e1004825. doi: 10.1371/journal.pgen.1004825

Figure 7. Schematic diagram showing the proposed model of RANBP9 function during spermatogenesis in mice.

Figure 7

In the nuclei of spermatocytes (including leptotene, zygotene, pachytene and diplotene) and spermatids, RANBP9 binds key splicing factors (e.g. SF3B3, HNRNPM), and poly(A) binding proteins (PABPC1/2), to coordinate proper alternative splicing of its target mRNA transcripts. Correctly spliced, mature mRNAs are subsequently exported to the cytoplasm to function in spermatocytes and spermatids. Green arrows denote export of processed mRNAs from the nucleus to the cytoplasm.