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. 2014 Dec 4;10(12):e1004535. doi: 10.1371/journal.ppat.1004535

Figure 7. Viral exocytosis occurs most frequently near patches of LL5β.

Figure 7

(A–B) Cells were transduced to express mRFP-LL5β, infected with PRV 486 expressing gM-pHluorin, and imaged at 4.5–5 hr after PRV infection. Data represent 150 exocytosis events in 9 independent experiments. Scale bars represent 2 µm in all images. (A) Image is a maximum difference projection depicting exocytosis events over a 10 min time course. Particle exocytosis events are classified according to their proximity to mRFP-LL5β patches (yellow circles), or lack thereof (green squares). (B) Still images of a single exocytosis event, corresponding to Movie S6. (C) Schematic of molecular and cellular mechanisms that coordinate viral transport and exocytosis. Please refer to the discussion section for references supporting the depicted molecular links.