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. 2014 Dec 4;10(12):e1004820. doi: 10.1371/journal.pgen.1004820

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© 2014 Zhou et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Col10a1-Cre;ROSA-tdTomato embryos were generated to verify the observations made in the Col10a1-Cre;Osx ^flox/+ embryos. Abundant Tomato⁺ non-chondrocytic cells (red) were present throughout the primary spongiosa in femurs of E15.5 (A), E16.5 (B) and E18.5 (C) Col10a1-Cre;ROSA-tdTomato embryos (right panels). Tomato⁺ non-chondrocytic cells were completely absent from the ROSA-tdTomato control embryos in all stages evaluated (left panels in A and B, upper panel in C). Upper panels in A and B and middle panel in C: red channel; Lower panels: red and blue channels. Right panels in C: magnified images. There were virtually no Tomato⁺ cells within the perichondrium (between white arrows) or periosteum (between white arrowheads) of the Col10a1-Cre; ROSA-tdTomato embryos. gp: growth plate (white brackets); ps: primary spongiosa; bm: bone marrow.