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. 2014 Dec 4;10(12):e1004832. doi: 10.1371/journal.pgen.1004832

Figure 4. mtSSB in vivo occupancy reflects strand-displacement mtDNA replication.

Figure 4

(A) Occupancy of mtSSB and TFAM analyzed by strand-specific qPCR amplification of ChIP samples. (B) Strand-specific ChIP-seq profile of mtSSB binding to mtDNA. The origins of replication are indicated. The short black bars indicate the location of the primers used for strand-specific qPCR. (C) Schematic illustration of expected occupancy of mtSSB accordingly to the different mtDNA replication models. SDM (Strand displacement mode), SC (Strand coupled mode), and RITOLS.