Table 1. Mttp inactivation lowers plasma cholesterol in the treatment vs. control groups.

Group	Number of animals	Plasma total cholesterol level (mg/dL)
baseline	7	903±71
vehicle, day 7	5	424±59
Mttp-inactivated, day 7	5	148±12
vehicle, day 14	5	307±62
Mttp-inactivated, day 14	5	107±16

Reversa mice were fed a Western diet for 16 weeks. One group of animals was sacrificed at 16 weeks as the baseline group. The rest of the mice were switched to chow diet and assigned to two groups, vehicle and Mttp-inactivated; animals within these two groups received injections of saline or poly I:C, respectively (see Methods). Animals were sacrificed on day seven or day 14 after the injections, and plasma total cholesterol levels were measured (see Methods). Measurements are summarized as mean ± SE.