Table 1. Upstream regulator analysis of 192 up-regulated genes from mouse feet at day 30 post CHIKV infection compared to day 0.
| Upstream Regulator | Activation z-score | p-value of overlap |
| Type I IFN responses | ||
| Ifnar | 4.5 | 1.4E-27 |
| IFNB1 | 3.8 | 1.4E-23 |
| IRF7 | 4.3 | 5.9E-20 |
| STAT1 | 4.3 | 2.4E-17 |
| IRF3 | 3.6 | 7.4E-16 |
| TLR3 | 3.6 | 2.4E-14 |
| Interferon alpha | 4.4 | 5.1E-14 |
| IFNL1 | 3.4 | 7.5E-14 |
| IFNAR1 | 2.8 | 3.6E-13 |
| IFN Beta | 3.4 | 6.5E-13 |
| IFNA2 | 3.7 | 2.0E-12 |
| IFN alpha/beta | 3.3 | 5.6E-12 |
| IFNA1/IFNA13 | 2.9 | 8.5E-12 |
| TLR4 | 3.3 | 1.3E-11 |
| IFN type 1 | 2.9 | 2.2E-11 |
| DDX58 (RIG-I) | 2.0 | 4.0E-11 |
| IFNE | 2.4 | 8.3E-11 |
| IFNK | 2.2 | 1.1E-10 |
| IKBKE | 0.1 | 9.7E-10 |
| Negative regulators of type I IFN responses | ||
| SOCS1 | −3.9 | 4.6E-20 |
| TRIM24 | −4.1 | 9.4E-20 |
| mir-21 | −3.8 | 1.0E-17 |
| Cytokines | ||
| IFNγ (Th1) | 6.3 | 1.1E-21 |
| IL12 (complex) (Th1) | 1.8 | 5.7E-11 |
| IL6 | 3.9 | 6.7E-10 |
| T cell responses | ||
| DOCK8 | 3.2 | 3.6E-11 |
| TCR | 0.5 | 5.3E-11 |
| Apoptosis | ||
| PARP1 | 3.1 | 1.6E-10 |
| M2 differentiation | ||
| STAT3 | 2.3 | 2.5E-10 |
| Autophagy | ||
| IRGM | −2.8 | 3.8E-10 |
| Others | ||
| PLK4 | 2.6 | 2.2E-10 |
| PLK2 | 2.6 | 3.0E-10 |
| FZD9 | 2.4 | 9.2E-10 |
All upstream regulators with a p value <10e-9 are listed. A positive z-score indicates that the identified regulator is activated, since it normally up-regulates specific genes found in the 192 gene set. Similarly, a negative z-score indicates that the identified regulator is inhibited, since it normally down-regulates specific genes found in the 192 gene set. The full data set from this analysis with associated lists of up-regulated genes is shown in S4 Table in S1 Text.