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Female CD-1 mice were immunized 3 times at 14-day intervals by the IP route starting at day 0. Blood and fecal samples were collected on days −1, 21, and 42. Following the final bleed, the females were mated 1-to-1 with 12-week old male CD-1 mice. The females were monitored for birth and 6-day old pups were used for challenge with live V. cholerae N16961.
