FIGURE 1.

Structure of RNF207. Structural comparison of cardiac RNF207 from human, mouse, and rabbit with zebrafish RNF207. The conserved RING (C-x₂-C-x₁₁-C-x₂-H-x₂-C-x₂-C-x₁₁-C-x₂-C), B-box 1 (C-x₂-C-x₁₄-C-x₂-C-x₄-C-x₂-C-x₄-H-x₇-H) and B-box C-terminal (BBC) domains as well as a C-terminal homologous region (CHR) that contains no known protein domain, are depicted. No sequence homology is found in the C-terminal non-homologous region (CNHR). Also shown is the SNP (G603A) in human RNF207, which is associated with QT interval prolongation (10, 11, 16).