Structure of RNF207. Structural comparison of cardiac RNF207 from human, mouse, and rabbit with zebrafish RNF207. The conserved RING (C-x2-C-x11-C-x2-H-x2-C-x2-C-x11-C-x2-C), B-box 1 (C-x2-C-x14-C-x2-C-x4-C-x2-C-x4-H-x7-H) and B-box C-terminal (BBC) domains as well as a C-terminal homologous region (CHR) that contains no known protein domain, are depicted. No sequence homology is found in the C-terminal non-homologous region (CNHR). Also shown is the SNP (G603A) in human RNF207, which is associated with QT interval prolongation (10, 11, 16).