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Biosynthesis and metabolism of 2-AG. Following production of 2-AG, lipases (MAG lipase, ABHD6 and -12, CES1, and PPT1) can hydrolyze 2-AG to AA, which can be oxidized to form prostaglandins (PGE2 shown here). Additionally, 2-AG is oxidized by COX-2 to form PG-Gs (PGE2-G shown here). PG-Gs can be hydrolyzed by CES1, PPT1, and/or other enzymes to form the corresponding free acid prostaglandins. DAG, diacylglycerol.
