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Inhibition of LYPLA2 by small molecule inhibitors. A, chemical structures and IC50 values for Compound 1 (LYPLA2 inhibitor), Compound 21 (LYPLA1 inhibitor), JZl-184 (MAGL inhibitor), and PGE2-SA (structural analog of PGE2-G). B, inhibition curves of LYPLA2-mediated hydrolysis of PGE2-G by Compound 1 (■), Compound 21 (●), and PGE2-SA (▴). Data are presented as the mean ± S.D. of triplicate analyses.
