TABLE 2.
Clinical characteristics of rats with hypertrophic, non-failing (ABHT) and failing (ABHF) hearts compared with sham-operated controls
LVDd/s, LV diameter in diastole and systole; FS, fractional shortening in LVD; PWd, posterior wall thickness in diastole; LAD, left atrial diameter; LVOT, LV outlet tract; CO, cardiac output.
| Sham | ABHT | ABHF | |
|---|---|---|---|
| Number (n) | 14 | 10 | 10 |
| Body weight (g) | 357 ± 6 | 332 ± 7a | 338 ± 13 |
| Heart weight (g) | 0.96 ± 0.03 | 1.53 ± 0.05a | 2.7 ± 0.13a,b |
| LV weight (g) | 0.56 ± 0.03 | 0.97 ± 0.02a | 1.3 ± 0.05a,b |
| LV/body weight ratio (mg/g) | 1.58 ± 0.08 | 2.92 ± 0.09a | 4.0 ± 0.22a,b |
| Lung weight (g) | 1.11 ± 0.06 | 1.55 ± 0.04a | 4.0 ± 0.14a,b |
| LVDd (mm) | 6.2 ± 0.1 | 5.4 ± 0.1a | 7.5 ± 0.2a,b |
| LVDs (mm) | 3.0 ± 0.2 | 2.2 ± 0.1a | 4.5 ± 0.3a,b |
| FS (%) | 57 ± 2 | 59 ± 2 | 40 ± 3a,b |
| PWd (mm) | 1.6 ± 0.04 | 2.3 ± 0.1a | 2.4 ± 0.1a |
| LAD (mm) | 3.4 ± 0.1 | 4.2 ± 0.1a | 6.1 ± 0.3a,b |
| Peak mitral flow (mm/s) | 859 ± 30 | 925 ± 47 | 1076 ± 42a,b |
| Mitral deceleration (mm/s) | 2714 ± 145 | 3314 ± 242a | 4940 ± 418a |
| Peak LVOT flow (mm/s) | 1087 ± 62 | 917 ± 39a | 824 ± 90 |
| Heart rate | 430 ± 6 | 416 ± 12 | 383 ± 8a |
| CO in LVOT (ml/min) | 129 ± 6 | 115 ± 7 | 103 ± 12 |
| Maximal velocity (mm/s) | 73 ± 3 | 51 ± 3a | 38 ± 4a,b |
| Minimal velocity (mm/s) | 78 ± 3 | 56 ± 4a | 51 ± 3a |
a p < 0.05 versus sham.
b p < 0.05 versus ABHT.