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Comparison of overall structure and active sites of L. pneumophila LppA and S. ruminantium PhyA. A, overlay of the overall structures; B, close-up view of the catalytic P-loop sites of L. pneumophila LppA (green) and S. ruminantium PhyA (red) binding two phosphates (green) or the inhibitor myo-inositol hexasulfate (IHS; red), respectively.
