FIGURE 6.

Identification of common targets of IRF8 and BCOR in the human OCI-Ly1 B cell line. A, Venn diagram showing IRF8 and BCOR targets in OCI-Ly1 human diffuse large B cell lymphoma cells analyzed by ChIP-chip (gray line) and ChIP-sequencing (ChIP-seq) (black line), respectively. One thousand eight hundred sixteen genes were identified as putative common IRF8 and BCOR targets. B, co-occupancy by BCOR and IRF8 in BANK1, CD74, and TLR4 fragments. Formaldehyde-fixed chromatin from OCI-Ly1 cells was precipitated by anti-BCOR and subjected to ReChIP by anti-IRF8 antibody. DNA was recovered and amplified with primer sets for each target gene. NTC, non-template control.