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. 2014 Dec 4;9(12):e112454. doi: 10.1371/journal.pone.0112454

Figure 6. IVD explant response to IL-1ß.

Figure 6

(a) When treated with IL-1ß at 10 ng/mL for 12 hours, IVD explants demonstrate significant decreases in gene expression of COL2 (p = 7.4×10−11) and ACAN (p = 3.0×10−5); ADAMTS4 (p = 0.009) gene expression is increased. Values are normalized to GAPDH. Results are presented relative to IVDs cultured without IL-1ß where the expression value was set to 1 (b) Murine IVD explants demonstrate increased MAPK phosphorylation when treated with IL-1ß at 10 ng/mL for 24 hours. * denotes statistical significance (p<0.05).