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. 2014 Dec 4;9(12):e112454. doi: 10.1371/journal.pone.0112454

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© 2014 Pelle et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Real-time PCR analysis of murine IVD explant gene expression response to stimulation with exogenously administered TGF-ß3 (10 ng/mL for 24 hours) demonstrates significant increase in the gene expressions of ACAN and TIMP1. Values are normalized to GAPDH. Results are presented relative to IVDs cultured without TGF-ß3 where the expression value was set to 1. Values are normalized to GAPDH. (b) Murine IVDs from TGFßR1^fl/fl demonstrate significant upregulation in ACAN gene expression when cultured with cre-expressing adenovirus. Exogenous TGF-ß3 at 10 ng/mL for 24 hours was cultured with wild-type murine IVDs. Results are presented relative to IVDs cultured with control adenovirus where the expression value was set to 1. Values are normalized to GAPDH. * denotes statistical significance (p<0.05). ns denotes not statistically significant (p>0.05).