Table 2. Summary of transcripts (29 probe sets for 26 genes) dysregulated in the overlap of comparisons between dorsal trichoblastomas versus tail papillomas and dorsal trichoblastomas and facial papillomas.
AffymetrixID | *DL vs. TL | p-value | q-value | *DL vs. FL | p-value | q-value | IPA ID | Gene | Description | Location | Family |
10353028 | 1.2142 | 0.0003 | 0.0025 | 1.2483 | 0.0005 | 0.0214 | 10353028 | Vcpip1 | valosin containing protein (p97)/p47 complex interacting protein 1 | Cytoplasm | peptidase |
10360720 | −1.1487 | 0.0123 | 0.0267 | −1.217 | 0.0018 | 0.0391 | 10360720 | Wdr26 | WD repeat domain 26 | Cytoplasm | other |
10364038 | 1.2426 | 0.0164 | 0.033 | 1.4241 | 0.0013 | 0.0337 | 10364038 | Upb1 | ureidopropionase, beta | Cytoplasm | enzyme |
10368199 | −1.4208 | 0.0177 | 0.0349 | −2.2868 | 0.0005 | 0.0214 | 10368199 | Myb | v-myb myeloblastosis viral oncogene homolog (avian) | Nucleus | transcription regulator |
10421810 | 1.2775 | 0.0031 | 0.0102 | 1.3348 | 0.0024 | 0.0455 | 10421810 | Rgcc | regulator of cell cycle | Cytoplasm | other |
10434806 | 1.192 | 0.0038 | 0.0117 | 1.3013 | 0.0023 | 0.0443 | 10434806 | Lpp | LIM domain containing preferred translocation partner in lipoma | Nucleus | other |
10436451 | −1.3819 | 0.002 | 0.0075 | −1.8319 | 0.0008 | 0.0274 | 10436451 | Stx19 | syntaxin 19 | Other | other |
10436967 | 1.2058 | 0.0163 | 0.0329 | 1.257 | 0.0024 | 0.045 | 10436967 | Cbr1 | carbonyl reductase 1 | Cytoplasm | enzyme |
10443391 | −1.1728 | 0.0106 | 0.0241 | −1.3165 | 0.0027 | 0.0478 | 10443391 | Mapk14 | mitogen-activated protein kinase 14 | Cytoplasm | kinase |
10445574 | 1.3044 | 0.0014 | 0.0061 | 1.434 | 0.0025 | 0.0462 | 10445574 | Cul7 | cullin 7 | Cytoplasm | other |
10454286 | −1.8277 | 0.0003 | 0.0026 | −1.6974 | 0.0008 | 0.027 | 10454286 | Mapre2 | microtubule-associated protein, RP/EB family, member 2 | Cytoplasm | other |
10455395 | −1.4012 | 0.0011 | 0.0051 | −1.5692 | 0.0018 | 0.04 | 10455395 | Spink5 | serine peptidase inhibitor, Kazal type 5 | Extracellular Space | other |
10489092 | 1.2599 | 0.001 | 0.005 | 1.2368 | 0.0018 | 0.0401 | 10489092 | Soga1 | suppressor of glucose, autophagy associated 1 | Extracellular Space | other |
10489831 | 1.1783 | 0.0003 | 0.0028 | 1.1251 | 0.0016 | 0.0374 | 10489831 | Stau1 | staufen, RNA binding protein, homolog 1 (Drosophila) | Cytoplasm | transporter |
10491272 | −1.2368 | 0.0285 | 0.0493 | −1.4175 | 0.0009 | 0.0282 | 10491272 | Gpr160 | G protein-coupled receptor 160 | Plasma Membrane | G-protein coupled receptor |
10495001 | 1.162 | 0.0102 | 0.0234 | 1.2775 | 0.001 | 0.0297 | 10495001 | Rsbn1 | round spermatid basic protein 1 | Nucleus | other |
10500122 | −1.1594 | 0.0132 | 0.0281 | −1.5018 | 0.0004 | 0.0196 | 10500122 | Bnipl | BCL2/adenovirus E1B 19 kD interacting protein like | Cytoplasm | other |
10530819 | −1.5511 | 0.0007 | 0.004 | −1.7695 | 0.0016 | 0.0375 | 10530819 | Hopx | HOP homeobox | Nucleus | transcription regulator |
10531323 | 1.1408 | 0.0179 | 0.0353 | 1.2426 | 0.0019 | 0.0414 | 10531323 | G3bp2 | GTPase activating protein (SH3 domain) binding protein 2 | Nucleus | enzyme |
10537026 | −1.234 | 0.0186 | 0.0362 | −2.5491 | 0.0001 | 0.0093 | 10537026 | Cpa4 | carboxypeptidase A4 | Extracellular Space | peptidase |
10561837 | 1.1674 | 0.0158 | 0.0322 | 1.2687 | 0.0016 | 0.0374 | 10561837 | Znf146 | zinc finger protein 146 | Nucleus | other |
10569923 | −1.1647 | 0.0133 | 0.0282 | −1.6133 | 0.0009 | 0.028 | 10569923 | Lrrc8e | leucine rich repeat containing 8 family, member E | Other | other |
10573803 | 1.217 | 0.0122 | 0.0266 | 1.4573 | 0.0027 | 0.0477 | 10573803 | Cyld | cylindromatosis (turban tumor syndrome) | Nucleus | transcription regulator |
10583647 | −1.1434 | 0.0071 | 0.018 | −1.2512 | 0.0008 | 0.0266 | 10583647 | Dnm2 | dynamin 2 | Plasma Membrane | enzyme |
10595856 | 1.2002 | 0.0191 | 0.0369 | 1.4473 | 0.0022 | 0.0434 | 10595856 | Slc25a36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | Cytoplasm | transporter |
10597162 | −1.1947 | 0.0149 | 0.0307 | −1.4012 | 0.0008 | 0.0265 | 10597162 | Klhl18 | kelch-like family member 18 | Other | other |
Several oncogenes and cell cycle regulatory genes are identified. However, while statistically significant, fold changes in all cases are relatively minor suggesting a great deal of interaction may be necessary for viral induced tumors to differentiate into benign and productive papillomas rather than locally aggressive cancers. (*Fold changes; p-value and q-value<0.05).