Table 3. Many transcripts are commonly associated with carcinomas in two stage chemical carcinogenesis and UV light induced cutaneous cancers.
| Symbol | Entrez Gene Name | Entrez | Affymetrix | Location | Family | DL vs.FL | DLvs. FL | DL vs.TL | DLvs. TL | DL vs.DS | DLvs. DS | TL vs.TS | TL vs.TS | DS vs.TS | DS vs.TS |
| Gene ID | ID | (FoldChange) | (p-value) | (FoldChange) | (p-value) | (FoldChange) | (p-value) | (FoldChange) | (p-value) | (FoldChange) | (p-value) | ||||
| Nt5e | 5′-nucleotidase,ecto (CD73) | 23959 | 10587639 | PlasmaMembrane | Phosphatase | 1.1701 | 0.2472 | 2.6329 | 0.0011 | 1.2658 | 0.0578 | −2.0515 | 0.0024 | 1.0140 | 0.3742 |
| Krt15 | keratin 15 | 16665 | 10391025 | Cytoplasm | Other | −1.0281 | 0.6567 | 2.5669 | 0.0015 | −1.1147 | 0.3017 | −1.8877 | 0.0041 | 1.5157 | 0.0078 |
| Sox4 | SRY (sexdeterminingregion Y)-box 4 | 20677 | 10408450 | Nucleus | transcriptionregulator | 1.2687 | 0.2394 | 1.8575 | 0.0022 | −1.1540 | 0.1892 | −1.7013 | 0.0043 | 1.2599 | 0.0353 |
| Trp53 | tumorprotein p53 | 22059 | 10377550 | Nucleus | transcriptionregulator | 1.0968 | 0.2757 | 1.3566 | 0.0025 | 1.1728 | 0.0347 | −1.0070 | 0.5749 | 1.1487 | 0.0241 |
| Lgr5 | leucine-richrepeatcontainingG protein-coupledreceptor 5 | 14160 | 10372503 | PlasmaMembrane | G-proteincoupledreceptor | −1.1594 | 0.4595 | 2.7574 | 0.0036 | −1.2255 | 0.2888 | −2.9485 | 0.0045 | 1.1460 | 0.2565 |
| Cd34 | CD34 molecule | 12490 | 10352905 | PlasmaMembrane | Other | −2.1189 | 0.0389 | 1.5440 | 0.0046 | −2.0705 | 0.0042 | −1.6702 | 0.0044 | 1.9141 | 0.0012 |
| Ptch1 | patched 1 | 19206 | 10410039 | PlasmaMembrane | transmembrane receptor | −1.3044 | 0.3296 | 1.6021 | 0.0072 | −2.3080 | 0.0048 | −1.9634 | 0.0039 | 1.8834 | 0.0022 |
| Bnc2 | basonuclin 2 | 242509 | 10514177 | Nucleus | Other | −1.0070 | 0.6822 | 2.0849 | 0.0078 | −1.2198 | 0.2774 | −2.6820 | 0.0047 | −1.0546 | 0.3455 |
| Trp63 | tumor protein p63 | 22061 | 10434815 | Nucleus | transcriptionregulator | 1.1355 | 0.1975 | 1.1728 | 0.0103 | 1.2170 | 0.0120 | −1.1434 | 0.0271 | −1.1865 | 0.0063 |
| Krt1 | keratin 1 | 16678 | 10432852 | Cytoplasm | Other | −1.2894 | 0.0234 | −1.1947 | 0.0140 | 1.1173 | 0.1045 | 1.2058 | 0.0165 | −1.1070 | 0.0670 |
| Ncdn | neurochondrin | 26562 | 10516427 | Cytoplasm | Other | −1.0163 | 0.6246 | −1.1810 | 0.0144 | 1.1225 | 0.0825 | 1.1045 | 0.1074 | −1.2002 | 0.0081 |
| Krt10 | keratin 10 | 16661 | 10390831 | Cytoplasm | Other | −1.2658 | 0.0669 | −1.1865 | 0.0262 | −1.1173 | 0.1365 | −1.0842 | 0.2350 | −1.1514 | 0.0393 |
| Ctnnb1 | catenin(cadherin-associatedprotein), beta1, 88 kDa | 12387 | 10590325 | Nucleus | transcription regulator | −1.0425 | 0.4810 | 1.1460 | 0.0311 | 1.0619 | 0.2507 | −1.1225 | 0.0737 | −1.0401 | 0.2360 |
| Lgr6 | leucine-richrepeatcontaining G protein-coupledreceptor 6 | 329252 | 10357965 | PlasmaMembrane | G-proteincoupledreceptor | −1.2368 | 0.3612 | 1.3629 | 0.0369 | −1.2894 | 0.1030 | −1.6818 | 0.0085 | 1.0449 | 0.3280 |
| Gli2 | GLI family zinc finger 2 | 14633 | 10357137 | Nucleus | transcriptionregulator | 1.0000 | 0.6887 | 1.3629 | 0.0374 | −1.2340 | 0.1518 | −1.2687 | 0.1116 | 1.3256 | 0.0398 |
| Bmp6 | bonemorphogenetic protein6 | 12161 | 10404686 | Extracellular Space | growth factor | −1.7371 | 0.0420 | −1.2628 | 0.0438 | −1.1620 | 0.1777 | −1.1460 | 0.2147 | −1.2454 | 0.0416 |
| Gli1 | GLI family zinc finger 1 | 14632 | 10373179 | Nucleus | transcriptionregulator | −1.2805 | 0.2916 | 1.3256 | 0.0487 | −2.1140 | 0.0062 | −1.7451 | 0.0067 | 1.6058 | 0.0061 |
| Sox2 | SRY (sexdeterminingregion Y)-box2 | 20674 | 10491477 | Nucleus | transcriptionregulator | −1.2340 | 0.5268 | −1.1251 | 0.0605 | −1.0767 | 0.2125 | 1.0353 | 0.4382 | −1.0093 | 0.3707 |
| Hdgfrp3 | hepatoma-derivedgrowth factor,related protein 3 | 29877 | 10565193 | Nucleus | Other | 1.0918 | 0.2822 | −1.1728 | 0.0661 | 1.0187 | 0.4871 | −1.1810 | 0.0808 | −1.4109 | 0.0037 |
| Krt75 | keratin 75 | 109052 | 10432746 | Cytoplasm | Other | −2.7384 | 0.1060 | 2.0186 | 0.0867 | 2.0467 | 0.1221 | −3.1095 | 0.0269 | −3.1529 | 0.0146 |
| Lor | loricrin | 16939 | 10499870 | Cytoplasm | Other | −1.3787 | 0.0614 | 1.1251 | 0.0896 | −1.1810 | 0.0569 | −1.4473 | 0.0038 | −1.0892 | 0.1298 |
| Krt71 | keratin 71 | 56735 | 10432799 | Cytoplasm | Other | −3.4983 | 0.2131 | 2.3187 | 0.1018 | 4.2281 | 0.0370 | −3.3714 | 0.0502 | −6.1475 | 0.0068 |
| Hras | v-Ha-rasHarvey ratsarcoma viraloncogenehomolog | 15461 | 10569071 | PlasmaMembrane | Enzyme | −1.0473 | 0.5414 | −1.0943 | 0.1195 | 1.0644 | 0.2593 | −1.0497 | 0.3619 | −1.2226 | 0.0078 |
| Smo | smoothened,frizzled familyreceptor | 319757 | 10536917 | PlasmaMembrane | G-proteincoupledreceptor | 1.0792 | 0.2169 | 1.1045 | 0.1913 | 1.2170 | 0.0695 | 1.0595 | 0.4119 | −1.0401 | 0.2981 |
| Gli3 | GLI familyzinc finger 3 | 14634 | 10403727 | Nucleus | transcriptionregulator | 1.4540 | 0.0711 | 1.1514 | 0.2241 | 1.0093 | 0.5282 | −1.6935 | 0.0097 | −1.4845 | 0.0150 |
| Sufu | suppressor offused homolog(Drosophila) | 24069 | 10463645 | Nucleus | transcriptionregulator | −1.0473 | 0.4255 | 1.0842 | 0.2256 | 1.1355 | 0.1527 | 1.1487 | 0.1235 | 1.0968 | 0.1464 |
| Shh | sonichedgehog | 20423 | 10528872 | Extracellular Space | Peptidase | −1.0546 | 0.6215 | 1.1594 | 0.2292 | −1.4845 | 0.0438 | −1.1892 | 0.2531 | 1.4473 | 0.0240 |
| Lphn1 | latrophilin 1 | 330814 | 10580056 | PlasmaMembrane | G-proteincoupledreceptor | −1.0968 | 0.3626 | 1.0595 | 0.2629 | −1.0449 | 0.3645 | −1.1865 | 0.0375 | −1.1947 | 0.0208 |
| Pax6 | paired box 6 | 18508 | 10474312 | Nucleus | transcriptionregulator | −1.0595 | 0.5476 | −1.0497 | 0.3166 | 1.0546 | 0.2649 | 1.0353 | 0.4101 | −1.0619 | 0.1439 |
| Krt14 | keratin 14 | 16664 | 10391052 | Cytoplasm | Other | 1.0867 | 0.5098 | −1.0210 | 0.3967 | 1.4340 | 0.0042 | 1.0892 | 0.1294 | −1.3441 | 0.0014 |
| Krt17 | keratin 17 | 16667 | 10391066 | Cytoplasm | Other | −1.1019 | 0.3117 | 1.0140 | 0.4610 | 1.1460 | 0.1135 | 1.5122 | 0.0035 | 1.3379 | 0.0046 |
Many had no significant changes, and those that did, in general, the changes were not high. Some of the keratins are downregulated in the dorsal skin trichoblastomas compared to the tail and facial skin papillomas which corresponds to the immunohistochemical results.