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. 2014 Dec 4;9(12):e113893. doi: 10.1371/journal.pone.0113893

Figure 5. zag-1 and ceh-28 function in a hierarchy in the M4 neuron.

Figure 5

Model indicating gene regulatory interactions in M4 discussed in the text. CEH-28 is necessary to activate expression of dbl-1, egl-17, and flp-5. CEH-28 also activates zag-1 gene expression in a positive feedback loop. Either CEH-28, ZAG-1 or both activate flp-2 expression (dashed arrows). ZAG-1 functions upstream to activate ceh-28 and ser-7b expression, while another factor(s) activate zag-1, unc-17, and flp-21 (indicated as X).