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. 2014 Dec 4;9(12):e114034. doi: 10.1371/journal.pone.0114034

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© 2014 Tong et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Effect of I _K1 being partially replaced by a combination of I _KCNQ1 ( _KCNQ1 = 0.0032 nS pF⁻¹), I _KCNQ4 ( _KCNQ4 = 0.024 nS pF⁻¹) and I _hERG ( _hERG = 0.08 nS pF⁻¹). Note that I _b has been replaced with I _KCNQ5 ( _KCNQ5 = 0.016 nS pF⁻¹). With this configuration, long-duration bursting APs were induced (left panel) while the whole cell K⁺ currents (middle panel) and the I-V relationships (right panel) matched the experimental data [44] (© Wang et al., 1998). B. Summary of the electrogenic components of the modified USMC model.

Inline graphic — A, Effect of I _K1 being partially replaced by a combination of I _KCNQ1 ( _KCNQ1 = 0.0032 nS pF⁻¹), I _KCNQ4 ( _KCNQ4 = 0.024 nS pF⁻¹) and I _hERG ( _hERG = 0.08 nS pF⁻¹). Note that I _b has been replaced with I _KCNQ5 ( _KCNQ5 = 0.016 nS pF⁻¹). With this configuration, long-duration bursting APs were induced (left panel) while the whole cell K⁺ currents (middle panel) and the I-V relationships (right panel) matched the experimental data [44] (© Wang et al., 1998). B. Summary of the electrogenic components of the modified USMC model.