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. 2014 Dec 4;9(12):e114034. doi: 10.1371/journal.pone.0114034

Figure 9. Effects of changing KCNQ and hERG current conductances on the modified USMC model AP form.

Figure 9

Simulating the effects of increased expression of KCNQ subunits and reduction of HERG current in uterine smooth muscle cells during late term. The conductance values for I KCNQ and I hERG in the modified USMC model, as in Figure 7, are used as the reference values. Both I KCNQ1 and I KCNQ4 were changed by the same proportions. A, no I KCNQ1 or I KCNQ4; I hERG at 1 fold. B, I KCNQ1 and I KCNQ4 at 0.25 fold; I hERG at 1 fold. C, I KCNQ1, I KCNQ4 and I hERG at 1 fold. D, I KCNQ1 and I KCNQ4 at 1.25 fold; I hERG at 1 fold. E, I KCNQ1 and I KCNQ4 at 1.25 fold; I hERG at 0.6 fold. F, I KCNQ1 and I KCNQ4 at 1.25 fold; I hERG at 0.05 fold.