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. 2014 Dec 4;9(12):e114287. doi: 10.1371/journal.pone.0114287

Figure 1. AS101 prevents proteinuria and albuminuria but does not affect blood glucose levels in-vivo.

Figure 1

Diabetes was induced by single intraperitoneal injection of STZ (65 mg/kg). Mice were treated with AS101 at 0.5 mg/kg (Low dose - LD) or 1 mg/kg (High dose - HD) by intraperitoneal injection every other day. Control animals were treated with PBS alone. (a) Glucose levels were determined by Freestyle glucometer. *p<0.01 decrease vs. all other groups (n = 14 for Control; n = 12 for STZ+PBS; n = 15 for STZ+AS101 LD; n = 14 for STZ+AS101 HD). (b) Urine was collected by metabolic cage for 24 hours, and protein was determined by Bradford assay. *p<0.05 increase vs. STZ+HD and control groups. #p<0.01 increase vs. all other groups (n = 14 for Control; n = 12 for STZ+PBS; n = 15 for STZ+AS101 LD; n = 14 for STZ+AS101 HD). (c) Urine albumin was determined by ELISA. *p<0.05 increase vs. control. #p<0.05 decrease vs. PBS treated diabetic rats (n = 5 for Control; n = 6 for STZ+PBS; n = 9 for STZ+AS101 LD; n = 8 for STZ+AS101 HD).